Abstract
Objective: The increase of morbidity results from both an increase of life expectancy of the population, and influence of various risk factors contributing to development and increase of chronic heart failure (CHF). The combination of several atherogenic mechanisms (abdominal obesity (AO), insulin resistance (IR), arterial hypertension (AH), hyperglycemia, dyslipidemia), combined as “metabolic syndrome” (MS), causes a more rapid development of CHF. Materials and methods: The research finding of 74 patients with class II-III of CHF, including 37 patients (50%) with MS, are presented. The age structure of the pathology, severity of clinical course, data of laboratory and instrumental examination in various groups of patients were evaluated. A special program included an echocardiographic test with an assessment of various myocardial parameters. Results and Discussion: Research materials find out a number of characteristics of CHF clinical course (its earlier development and severe course) in patients with MS. Echocardiographic tests reveal an increase of heart chambers sizes, thickness of left and right ventricle, pulmonary hypertension. Myocardium morpho-functional changes are more significant in patients with CHF and MS than in those without MS. An increase in leptin levels, a marker of obesity, fibrosis and inflammation, has been found. Leptin, C-reactive peptide (CRP) and high-sensitive troponin in patients with MS significantly exceeded those in patientswithout MS. Correlations of leptin levels, adiponectin, CRP and left ventricular mass, thickness of epicardial fat (TEF), ejection fraction were established. Conclusion: Materials of the research indicate the important role of inflammatory and dysmetabolic processes in development and progression of CHF in patients with MS. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 105-113
Highlights
Chronic heart failure (CHF) is one of the most important medical and social problems due to its increasing prevalence in economically developed countries
C-reactive peptide (CRP) and high-sensitive troponin in patients with metabolic syndrome” (MS) significantly exceeded those in patientswithout MS
We examined 74 patients with CHF II-III functional class I-IV (FC), including 37 patients (50%) with signs of MS, who were treated at the City Clinical Hospital named after S.P
Summary
Chronic heart failure (CHF) is one of the most important medical and social problems due to its increasing prevalence in economically developed countries. More than 23 million people suffer from CHF worldwide.[1] According to the “ЭПОХА-ОХСН” study, in Russia about 7.9 million people have signs of CHF. The prevalence of functional class I-IV (FC) in the European part of the Russian Federation is 12.3% among women and 9.86% among men.[2] In the age group 70-79 years, the prevalence of CHF increases manifold, reaching 34.3%. The annual mortality rate in clinically expressed CHF is 612 thousand patients.[2]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
