Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

Pei Zhang,Bo Tian

doi:10.1155/2014/729194

Abstract

Metabolic syndrome is becoming commoner due to a rise in obesity rates among adults. Generally speaking, a person with metabolic syndrome is twice as likely to develop cardiovascular disease and five times as likely to develop diabetes as someone without metabolic syndrome. Increasing oxidative stress in metabolic syndrome and Parkinson's disease is mentioned in the comprehensive articles; however, the system review about clear relation between metabolic syndrome and Parkinson's disease is deficient. In this review, we will focus on the analysis that the metabolic syndrome may be a risk factor for Parkinson's disease and the preventions that reduce the incident of Parkinson's disease by regulating the oxidative stress.

Highlights

Metabolic syndrome is a prevalent and increasing public health problem worldwide related to many chronic diseases
Its components mainly include at least insulin resistance, central obesity, glucose intolerance, dyslipidemia with elevated triglycerides, low HDL cholesterol, microalbuminuria, predominance of small dense LDL-cholesterol particles, hypertension, endothelial dysfunction, high waist circumference, oxidative stress, inflammation, tumors, neurodegeneration, and atherosclerosis-based ischemic cardio- or cerebral-vascular disease
A growing number of studies have been completed to confirm that stimulation of oxidative stress that initiates apoptosis in many cells and animal models [11, 14, 41] is pivotal to the evolution of metabolic syndrome, diabetes, diabetic neuropathy, and several neurodegenerative disorders, such as Parkinson’s disease and Alzheimer disease [42,43,44,45,46]

Summary

Introduction

Metabolic syndrome is a prevalent and increasing public health problem worldwide related to many chronic diseases. Recent studies have indicated that increased oxidative stress is the core and a general character of metabolism-related disease. 2. The Components of Metabolic Syndrome Act as the Risk Factors for Parkinson’s Disease

Results

Conclusion