Metabolic Syndrome a Cornerstone in Cardiorenal Syndrome

Abstract

Objective: The purpose of the study was to evaluate the relationship of metabolic syndrome (MetS) and cardiorenal syndrome(CRS) type 4 in the early stage of chronic renal disease. Introduction: Metabolic syndrome is facing a continually increasing nowadays. That is why he is turning in to a worldwide problem. On the other hand, improving of life expectancy is associated with rising morbidity, which is also reflected in expanding number cardiorenal patients. Materials and Methods: We conducted an observational study.139 patients with chronic renal disease stage 3 and 4 were en-rolled Statistical analysis was performed by χ2 test, logistic regression, Fisher's exact test. Results: Cardiorenal syndrome was found in 85.6% of patients(pts). The mean age was 56.7 ± 12.5 years. Males were 60.4% patients. Metabolic syndrome was defined by NCEP -ATP III and was observed in 66.9% of patients, hypertension in 71.9% of pts, obesity in 68.3% of pts,diabetes mellitus in 78.4% of pts, dislipidemia in 71.9% of pts, and uricemia in 61.9% of pts. Study results showed that metabolic syndrome had a powerfull significant association with cardiorenal syndrome p≤0.002. Also, hypertension, obesity, dislipidemia, hyperuricemia ans diabetes had a strong relationship p≤0.05 with CRS. Conclusions: Cardiorenal syndrome is quite common even in the early stages of renal disease. Its linking with metabolic syndrome is very important. Our efforts should be focused in early recognition and timely identification of MetS compounds: obesity, hypertension, diabetes mellitus, so as to prevent and reduce morbidity and health costs these syndromes carried.