Metabolic surgery reduces increased urinary mitochondrial DNA copy number in obese patients

Abstract

At present, obesity has become an independent risk factor for chronic kidney disease through its direct or indirect effects. Urine mitochondrial DNA (mtDNA) is a new marker of mitochondrial damage in various kidney diseases, but the differences in urinary mtDNA between obese and healthy subjects and the effect of obesity intervention on urinary mtDNA copy number are unknown. In January 2019, The Journal of Clinical Endocrinology & Metabolism published an article Bariatric surgery reduces elevated urinary mitochondrial DNA copy number in obese patients [Lee H, Oh S, Yang W, et al. J Clin Endocrinol Metab, 2019, 104(6): 2257-2266], with the permission of the original journal, we translate the article into Chinses. This article studied the difference of urinary mtDNA levels between obese and healthy subjects and the changes of urinary mtDNA after metabolic surgery intervention. The results revealed that obesity was associated with the increase of urinary nicotinamide adenine dinucleotide dehydrogenase subunit 1 (mtND-1) copy number, and urinary mtDNA copy number was elevated in obese patients. Metabolic surgery reduced urinary mtND-1 copy number in obese patients. This study shows that metabolic surgery can alleviate mitochondrial damage in kidney cells in obese patients. Key words: Metabolic surgery; Obesity; Urinary mitochondrial DNA