Abstract
The effects of feeding isonitrogenous diets (at a restricted ration size), containing limiting or excessive amounts of lysine on various biochemical parameters of rats were investigated. Lysine α-ketoglutarate reductase (LKGR) and citrate synthase (CS) activities, hepatic portal vein (HPV) blood and liver free amino acid concentrations were measured in rats fed the experimental diets for up to 8 days. LKGR and CS activities remained constant in rats adapted to the lysine limiting diet. In contrast, LKGR activity rapidly increased (after 2 days) in rats fed the lysine excess diet and remained at a high level for the remainder of the experiment. The increase in liver LKGR activity in response to the lysine excess diet was associated with significant increases in HPV and liver free lysine concentrations (4.5- and 2-fold, respectively). The significance of these data are discussed with respect to the metabolic response of rats challenged with an increased lysine supply and its effects on free lysine concentrations and liver LKGR activity.
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