Abstract
Abstract Transcription factor forkhead box P3 (Foxp3)+ regulatory T (Treg) cells are receiving increasing attention because this unique subset of T cells is characterized by exerting negative regulatory function of cellular immune responses. The resultant suppression of anti-tumor immunity in the tumor microenvironment (TME) is regarded as a major obstacle to immunotherapies in a plethora of cancers. Thus, an integrated understanding of the intrinsic correlation between tumors and Treg cell biology is urgently required. This review focuses on the peculiar biochemical effects of tumor metabolic environments on Tregs and how Tregs orchestrate internal metabolic switches and altered metabolic pathways and molecules to survive and function after the remodeling of homeostasis and specialization, providing new directions for immunotherapies.
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