Abstract
The retina and its neighboring tissue, the retinal pigmented epithelium (RPE), require fuels for energy and anabolic activity. Each has unique metabolic features that they use synergistically to function together as a metabolic ecosystem. This article describes how nutrients reach the retina from the circulation. It then reviews the biochemistry of energy metabolism and describes specific metabolic interactions between the retina and RPE. Finally, the article reviews the relationships between energy metabolism and retinal diseases and it suggests how an understanding of those relationships may be used to develop treatments that slow the progression of several types of retinal degeneration.
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