Abstract
Metabolic Profiles of Clinical Strain of Staphylococcus aureus to Subtle Changes in the Environmental Parameters at Different Phases of Growth
Highlights
Infections due to staphylococcus aureus have been increased at a remarkable rate in the past era worldwide
Cultures of S. aureus were grown in tryptic soy broth media (TSB) to mid-exponential and stationary phases of growth under optimal conditions
The analysis indicated that significant changes in the relative abundances of many metabolites of cells grown to the stationary phase compared with those analysed at midexponential phase
Summary
Infections due to staphylococcus aureus have been increased at a remarkable rate in the past era worldwide. The processes involved in the adaptations of S. aureus in response to combination of environmental stresses are still not clear. It has been reported that staphylococcal adaptation mechanism in response to limited nutrients occurred through a significant changes in the patterns of enzymes and metabolites[7]. When S. aureus was grown under sub-optimal conditions, significant changes in the cytoplasmic amino acid, fatty acid and protein patterns were observed[6,8]. It was assumed that characteristic and specific changes in the amino acid and fatty acid metabolites as well as protein composition led to the survival of S. aureus when exposed to confined nutrition in combination with higher concentrations of NaCl9. A recent study indicated that hydrogen peroxide (H2O2) combined with various temperatures and pH induced alterations in the amino acid profiles of clinical isolate of S. aureus[10]
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