Abstract
Abstract AIMS The aim of this study was to investigate the effects of short-term food restriction (6-weeks) on metabolic profile and spontaneous physical activity (SPA) of young male Wistar rats. METHODS Thirty rats had their baseline SPA measured at 21 days-old and were separated into two groups at 28 days-old: Control (CG) and 50% of food restriction (FR). The food restriction protocol lasted six weeks, being the SPA measured weekly by a gravimetric apparatus. At the end of the experiment, biochemical analyses were performed in serum and tissue samples with statistical significance set at 5%. RESULTS FR showed less SPA than CG, as occurred for body mass, water intake, adipose tissue and liver, heart and soleus glycogen, serum glucose, total protein, triglycerides and total cholesterol (P<0.05). CONCLUSION Data set demonstrates that low substrate stores signaled to decrease spontaneous physical activity to save energy.
Highlights
Spontaneous physical activity (SPA) comprises all movements performed without consideration of the volitional or forced physical exercise 1, which represents an important component of the total daily energy expenditure 2 and to the control of energy balance and fat mass storage 3
Significant differences were not found in the same week in the measurement between groups (P>0.05), food restriction group (FR) showed less spontaneous physical activity (SPA) than control group (CG), demonstrating the diet effect on SPA outcomes (F=27.95; P
The main findings of the present study were that the short-term food restriction adopted leads to a significant decrease in SPA and significant modulations for the metabolic profile of the rats through time
Summary
Spontaneous physical activity (SPA) comprises all movements performed without consideration of the volitional or forced physical exercise 1, which represents an important component of the total daily energy expenditure 2 and to the control of energy balance and fat mass storage 3. Santos-Pinto 8 consistently postulated that the total daily energy expenditure, which is given by the sum of energy spent through thermic effect of food, resting metabolic rate and physical activity 9, is modulated in relation to food intake 8. It is well established that disproportional energy intake in relation to energy spent towards positive energy balance chronically leads to catastrophic consequences, firstly characterized by obesity and ectopic fat deposition in many tissues, such as liver, kidney and heart, promoting insulin resistance and metabolic syndrome. Food restriction (FR) protocols have been extensively employed in this context
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