Metabolic profile and inflammatory markers in an endurance trained and untrained population (884.20)

Abstract

Obesity is reaching epidemic proportions worldwide. Studies have now shown that obesity is the result of an imbalance in metabolic factors that have been triggered by a physiological stress resulting in an inflammatory state. Physical activity may positively impact metabolic dysfunction (insulin, glucose) and inflammatory markers, C‐reactive protein (CRP) and Interluekin‐6 (IL‐6), in adults, ultimately influencing one's risk for disease. With training, IL‐6 has been shown to elicit a pro‐ or anti‐inflammatory like state within the muscle; therefore it is a multi‐factorial cytokine. Whether there is a significant difference between endurance trained and untrained male and female adults in association to metabolic profile and inflammation markers is unknown. Therefore, the purpose was to examine the differences between body composition and metabolic profile (insulin, CRP, IL‐6, etc.) in trained (n=15, age 26.9 ± 14.4 yr) and untrained (n=19, age 36.7 ± 19.2 yr) adults. Fasting venous whole blood (40 ml) and body composition measurements (percent body fat, fat mass, etc.) were obtained from apparently healthy individuals. Enzyme‐linked immunosorbent assays were conducted to analyze fasting blood plasma concentrations of insulin, CRP, and IL‐6. An Independent T‐test was used to identify significant differences (p < 0.05) between trained and untrained (N=35). Significant differences exist in body composition (p < 0.05) and CRP (p < .001). Although fasting plasma insulin and IL‐6 were elevated in the untrained group, no significant differences were found. In conclusion, a significant difference exists between trained and untrained individuals for body composition and CRP suggesting that physical activity may decrease one’s risk of developing disease. Despite a significant difference with CRP in the trained versus untrained individuals, IL‐6 may elicit an anti‐inflammatory like property with endurance training ultimately protecting the trained individuals.Grant Funding Source: Supported by STEM