Metabolic perturbations in hypertrophic cardiomyopathy – Insights from human induced pluripotent stem cell-derived cardiomyocytes

Abstract

Hypertrophic cardiomyopathy (HCM) is one of the most commonly inherited cardiac disorders, and is defined as left ventricular hypertrophy without chamber dilation in the absence of an identifiable cause. It is characterised by cardiomyocyte hypertrophy and disarray, interstitial fibrosis, impaired left ventricular relaxation, and diastolic dysfunction, which can manifest in exercise intolerance, angina, dyspnoea, dizziness, syncope, or sudden cardiac death.