Abstract
Bacterial secondary metabolites exhibit several biological properties and many among them are pharmacologically important. Secondary metabolites are assembled by a variety of enzymatic pathways using l-chiral, d-chiral, and nonproteinogenic amino acids, as well as by using acetate units derived from various acyl-CoA esters. The nascent secondary metabolites are further modified by tailoring enzymes for biotechnological applications to attain the intended function. The production of secondary metabolites via several biochemical pathways generally occurs during the late phase of bacterial growth. These compounds protect bacteria during harsh environmental conditions and also act as antibacterial agents against other environmental microorganisms during competition for nutrients. Indirectly, these metabolites have both deleterious and beneficial effects on human health, nutrition, and economy of our society. This review will emphasize the formation of secondary metabolites using nonribosomal peptide synthase, polyketide synthase, shikimate pathways, and β-lactam pathways for uses in the pharmaceutical, food, and agriculture industries.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.