Abstract
Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly studied on physiology processes by analyzing a single gene function. A canonical correlation analysis was used to identify the metabolic pathways, which were integrated as a unit to coexpress with CAD susceptibility genes, and to resolve additional metabolic factors that are related to CAD. Seven pathways, including citrate cycle, ubiquinone, terpenoid quinone biosynthesis, and N-glycan biosynthesis, were identified as an integrated unit coexpressed with CAD genes. These pathways could not be revealed as a coexpressed pathway through traditional methods as each single gene has weak correlation. Furthermore, sets of genes in these pathways were candidate markers for diagnosis and detection from patients' serum.
Highlights
Coronary artery disease (CAD) is a leading cause of global death with several risk factors, including smoking, hypertension, diabetes, obesity, high blood lipids, and stress [1,2,3,4]
A clustering for the expression pattern of CAD and metabolic pathway genes was first created to estimate the possible gene group, which could provide an evidence for identifying the correlation among gene groups
A coexpression network was constructed among individual CAD and metabolic pathway genes
Summary
Coronary artery disease (CAD) is a leading cause of global death with several risk factors, including smoking, hypertension, diabetes, obesity, high blood lipids, and stress [1,2,3,4]. The current risk assessment of CAD is based on the determination of these factors. Almost all risk factors of CAD are related to metabolism in views of basic biological research. High blood lipids, which play an important role in causing CAD, is regulated by a complex metabolic network that involves the biosynthesis and degradation of cholesterol, triglycerides, and lipoproteins [7,8,9,10]. Another risk factor, diabetes, is a metabolic disease related to glucose [11, 12]. Pathophysiology and dietetics research have determined the close link between metabolism and CAD
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