Abstract
Background: HPV positive (HPV+) oropharyngeal squamous cell carcinomas (OPSCC) are characterised by extensive nodal disease, but are associated with significantly better outcome than HPV negative OPSCC. In head and neck SCC, high levels of lactate are associated with subsequent nodal and distant metastases and a ‘three compartment tumour metabolism’ model has been proposed in oral cancer. We investigated the metabolic status of HPV+ OPSCC.
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