Abstract
In contrast to bioreactors the metabolites within the microbial cells are converted in an impure atmosphere, yet the productivity seems to be well regulated and not affected by changes in operation variables. These features are attributed to integral metabolic network within the microorganism. With the advent of neo-integrative proteomic approaches the understanding of integration of metabolic and protein-protein interaction networks have began. In this article we review the methods employed to determine the protein-protein interaction and their integration to define metabolite networks. We further present a review of current understanding of network properties, and benefit of studying the networks. The predictions using network structure, for example, in silico experiments help illustrate the importance of studying the network properties. The cells are regarded as complex system but their elements unlike complex systems interact selectively and nonlinearly to produce coherent rather than complex behaviors.
Highlights
In contrast to bioreactors the metabolites within the microbial cells are converted in an impure atmosphere, yet the productivity seems to be well regulated and not affected by changes in operation variables
These features are attributed to integral metabolic network within the microorganism
The microbial proteome and proteomic approaches The analyses of proteome, the ensemble of proteins associated with a given cell, organelle or other sub-cellular component at a given physiological state of cells have been made possible by the sequencing of genome of a number of organisms
Summary
The microbial proteome and proteomic approaches The analyses of proteome, the ensemble of proteins associated with a given cell, organelle or other sub-cellular component at a given physiological state of cells have been made possible by the sequencing of genome of a number of organisms. The technique of synexpression has helped determine a number of interacting proteins for yeast cell-cycle analysis [22] and potential drug targets in rat brain by EST analyses [24]. Metabolic and protein-protein interaction network The cellular processes in a microorganism are seamlessly integrated through a complex network of constituent components and reactions.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
