Metabolic impact of the VDR rs1544410 in diabetic retinopathy.

Caroline Severo De Assis,Isabella Wanderley De Queiroga Evangelista,Rayner Anderson Ferreira Do Nascimento,Alexandre Sérgio Silva,Rafaela Lira Formiga Cavalcanti De Lima,Mayara Karla Dos Santos Nunes,Vanessa Polyana Alves De Sousa Brito,Tainá Gomes Diniz,João Otávio Scarano Alcântara,Darlene Camati Persuhn,Marina Gonçalves Monteiro Viturino,Kanhaiya Singh

doi:10.1371/journal.pone.0263346

Caroline Severo De Assis, Isabella Wanderley De Queiroga Evangelista + Show 10 more

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https://doi.org/10.1371/journal.pone.0263346

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Abstract

To investigate the association between BsmI and DM2 in patients with and without DR and to correlate with clinical parameters in a population in northeastern Brazil. Cross-sectional case-control study in which data were collected from 285 individuals, including 128 patients with DM2 and 157 with DR. Clinical, biochemical and anthropometric parameters were analyzed, in addition to the single nucleotide polymorphism (SNP) BsmI of the VDR gene (rs1544410), genotyped by PCR-RFLP. In the DR group we found a greater number of patients using insulin therapy (p = 0.000) and with longer duration of DM2 (p = 0.000), in addition to higher serum creatinine values (p = 0.001). Higher fasting glucose levels and higher frequency of insulinoterapy were independently observed in patients with DR and b allele carriers, when compared to BB. The association of the bb/Bb genotypes (rs1544410) of the VDR gene with increased blood glucose levels and insulinoterapy may represent worse glicemic control in rs1544410 b allele carriers in DR Latin American individuals.

Highlights

Diabetes mellitus is global epidemic health issue that affects around 415 million adults [1] Diabetic retinopathy (DR) is a frequent complication in type 2 Diabetes Mellitus (DM2) [2, 3], and clinical and metabolic factors are associated with the development and progression of DR [4–6].There is evidence that deficiency of Vitamin D (VD) is related to DM2 [7, 8]
In the DR group we found a greater number of patients using insulin therapy (p = 0.000) and with longer duration of DM2 (p = 0.000), in addition to higher serum creatinine values (p = 0.001)
The B allele of the BsmI polymorphism of the vitamin D receptor (VDR) gene was associated with a lower risk of DR in Korean patients with DM2 [14], and the bb genotype was associated with a decrease in (25 [OH] D) in micro and macrovascular complications of DM2 in an Indian population [15]

Summary

Introduction

Diabetes mellitus is global epidemic health issue that affects around 415 million adults [1] Diabetic retinopathy (DR) is a frequent complication in type 2 Diabetes Mellitus (DM2) [2, 3], and clinical and metabolic factors are associated with the development and progression of DR [4–6].There is evidence that deficiency of Vitamin D (VD) is related to DM2 [7, 8]. There is evidence that Vitamin D deficiency affects the pathogenesis and progression of DR and that patients with proliferative diabetic retinopathy (PDR) have lower levels of 25 (OH)D than those without diabetes [8, 12]. The relationship between vitamin D levels and DM2 and DR raises interest in investigating the effect of genetic aspects linked to this vitamin regarding its involvement in the etiology or modulation of DR, including single nucleotide polymorphisms (SNPs) in the Vitamin D receptor (VDR). The B allele of the BsmI polymorphism (rs1544410) of the VDR gene was associated with a lower risk of DR in Korean patients with DM2 [14], and the bb genotype was associated with a decrease in (25 [OH] D) in micro and macrovascular complications of DM2 in an Indian population [15]. There is no consensus in the literature on these relationships [13, 16–18], and the results seem to be influenced by the to geographic origin of patients

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