Abstract
Oxygen supply is known to have an important influence on microaerobic production of amino acids, some researches show that the behavior of many L-lysine producing microorganism under various aeration conditions are different. In present work, microaerobic lysine cultures under two dissolved oxygen concentrations were carried out using the strain of Corynebacterium glutamicum ATCC 21253. Although the growth rates of cells were slowed down under oxygen limitation, overall lysine molar yield on glucose did not decreased in comparison with aerobic fermentation with the same strain, on the contrary, a 30% increment of lysine yield exhibited in the culture with 5% DO concentration. A general metabolic framework was developed for this strain for obtaining detailed knowledge about the cellular metabolism in various culture conditions.
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