Abstract
The effect of intestinal microflora on the activities of NADP-dependent dehydrogenases in liver and kidneys, and on fatty acid synthetase, ATP-citrate lyse, cytochrome oxidase and succinate dehydrogenase activities in liver of rats were studied. Germfree rats showed a decrease in liver succinate dehydrogenase activity, and no effect on liver cytochrome oxidase activity. The absence of an intestinal microflora resulted in a significant decrease of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities, and a substantial increase of ATP-citrate lyase and fatty acid synthetase activities in the liver. Liver malate dehydrogenase activity was comparable in both germfree and conventional animals. Germfree status had no effect on the activities of NADP-dependent dehydrogenases in the kidney. It is concluded that the absence of an actively metabolizing microflora was associated with quantitative shifts in the activity of hepatic enzymes involved in the metabolism of carbohydrates and fats.
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