Abstract
Co-utilization of carbon sources in microbes is an important topic in metabolic engineering research. It is not only a way to reduce microbial production costs but also an attempt for either improving the yields of target products or decreasing the formation of byproducts. However, there are barriers in co-utilization of carbon sources in microbes, such as carbon catabolite repression. To overcome the barriers, different metabolic engineering strategies have been developed, such as inactivation of the phosphotransferase system and rewiring carbon assimilation pathways. This review summarizes the most recent developments of different strategies that support microbes to utilize two or more carbon sources simultaneously. The main content focuses on the co-utilization of glucose and pentoses, major sugars in lignocellulose.
Highlights
IntroductionAchieving high-yield and cost-effective microbial production of target products from lignocellulosic resources still have challenges from the laboratory scale to the industrial scale, one of which is how to achieve efficient utilization of the mixed sugars
Microbial production using renewable and economical carbon sources has been highly preferred to address the increasing concerns on the global energy shortage and climate change
Lignocellulosic biomass has become an attractive carbon source for microbial production in recent years, because its hydrolysates substantially offer several simple sugars, such as glucose and pentoses, that can be readily utilized by microorganisms [1]
Summary
Achieving high-yield and cost-effective microbial production of target products from lignocellulosic resources still have challenges from the laboratory scale to the industrial scale, one of which is how to achieve efficient utilization of the mixed sugars. Most microbes consume these mixed sugars sequentially or selectively due to the carbon catabolite repression (CCR), which prolongs the microbial production process and reduces the efficiency of carbon conversion. This review will summarize the recent efforts devoted to the strategies for eliminating CCR caused by different mixed carbon sources with the emphasis on co-utilization of glucose and pentoses
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
