Metabolic Effects of vitamin D Supplementation on Electrolyte balance and Pregnancy outcome of Preeclamptic women in south west, Nigeria.

Abstract

Objective: Preeclampsia (PE) remains a major cause of complications worldwide especially in sub-Saharan African countries like Nigeria. Vitamin D seems to be a viable agent in the management of preeclampsia through its influence on electrolyte balance. This study aimed at assessing the effects of vitamin D supplementation on electrolytes of preeclamptic women and investigate the role of vitamin D in the improvement of pregnancy outcome. Methods: 150 women were recruited at 22weeks gestation from antenatal clinics in Ibadan, Nigeria between year 2016 and 2018 and grouped into; 50 normotensive pregnant women( Group A) ,50 non supplemented preeclamptic women (Group B). 50 preeclamptic women were given 1000IU/day of Vitamin D3 for 8weeks after recruitment at 22weeks (Group C). Electrolytes , Creatinine (Cr) and Urea were quantified by standard methods. Results: The results obtained after supplementation with Vitamin D showed a significant decrease(p0.05) in gestational age at delivery, weight of fetus between the three groups ,while a significant reduction(p