Abstract
The studies described in this report were initiated in an effort to elucidate the mechanism of action of the sulfonylurea compounds. It seemed to us that a broad clinical investigative approach, involving the study of a large number of conditions in which the metabolism of carbohydrate is disturbed, was most likely to eliminate quickly a number of possible modeg of action and to define more sharply the areas upon which further effort should be concentrated. Thus, extensive metabolic-balance studies and numerous individual testing procedures have been performed before, during, and following the administration of carbutamide (BZ-55) and/or tolbutamide (Orinasei) in the following subjects: (1) healthy young men; (2) three middle-aged, obese, stable diabetics; ( 3 ) an unstable diabetic of normal weight; (4) a patient with lipo-atrophic diabetes; ( 5 ) a totally depancreatized woman; (6) patients with coexisting diabetes mellitus and Addison’s disease, familial diabetes and Cushing’s syndrome, and diabetes and panhypopituitarism; and (7) an acromegalic with mild diabetes. Although the data reported below do not define a specific mode of action of the sulfonylurea compounds, they eliminate from consideration a number of important possibilities. Results
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