Abstract
Paraquat-tolerant cells ofSaccharomyces cerevisiae were selected by growing the cells in medium supplemented with paraquat either in a continuous selection culture with UV irradiation of the cells or in shaker flasks. When tranferred to fresh medium containing 1.0 mM paraquat, the selected cells showed growth rates and product formation patterns very similar to those of normal cells grown in a medium without paraquat. In the presence of paraquat, cells that had developed a tolerance were able to metabolize the fermentation products formed from glucose. Normal cells were unable to do so for considerable time.
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