Abstract
SummaryMetabolic alterations caused by nitroglycerin were compared with those of tranylcypromine. Following administration of 100 μg/kg of nitroglycerin in unanesthetized rabbits, simultaneous elevations of plasma FFA (+98%), glycerol (+53%), lactate (+178%), and pyruvate (+135%) were observed. The same dose of nitroglycerin caused a significant elevation of plasma lactate but failed to increase plasma FFA and glycerol in reserpinized and propranolol-treated rabbits. Tranylcypromine (30 mg/kg) caused similar alterations: increase in plasma FFA (+135%), glycerol (+85%), lactate (+335%), and pyruvate (+152% Similarly, an increase in plasma lactate without change in plasma FFA and glycerol levels, was observed in reserpinized animals. An increase in body temperature was found in nitroglycerin- and tranylcypromine-treated rabbits, This effect was diminished when the two drugs were administered in reserpine-and propranolol-treated rabbits. These results indicate that the rate of lipolysis and glycolysis is inc...
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