Metabolic effects of acute measles in chronically malnourished Nigerian children

Abstract

We hypothesized that acute measles infection imposes severe metabolic demands on malnourished children. Nigerian rural communities, characterized by severe poverty and extensive malnutrition, served as site for this study. Sixty-five children (mean [±SD] age 2.67 ± 1.96 years) with measles and a randomly selected equal number of children (age 2.83 ± 1.23 years) from the same communities but measles-free were studied. Both groups were serologically negative for human immunodeficiency virus. The percentages of nonmeasles group who were underweight and wasted as exemplified by weight for age (WAZ) and weight for height (WHZ) scores less than −2.0 SD were 43% and 23%, respectively. Comparative values for the measles group (66% and 54% respectively) were significantly ( P < 0.01 or 0.001) different. Compared to the controls, measles-infected children had significantly ( P < 0.001) higher plasma cortisol level, marked hyporetinemia (plasma retinol 0.62 ± 0.24 μmol/L) and prominent reduction ( P < 0.002) in the sum of serum essential amino acids. Measles promoted a TH 1 to TH 2 cytokine shift, with severe depletion of plasma interleukin (IL)–12, a key cytokine in the development of cell mediated immunity. IL-6, a key stimulator of hepatic acute phase protein response, was prominently ( P < 0.002) increased in plasma in measles-infected children. Glucocorticoids exert effects on cytokine expression, as well as on cytokine receptor expression and cytokine-regulated biological responses. They enhance synergistically, the effects of IL-1 and IL-6 type cytokines on many acute phase proteins. Because of the prominent increase in circulating level of cortisol in acute measles, glucocorticoid treatment for associated sepsis may pose serious problems. Additionally, glucocorticoids antagonize several effects of retinoids at cellular and transcriptional levels, thus suggesting that hypercortisolemia may increase the requirement for retinoids.