METABOLIC DIFFERENCES BETWEEN MAIN TYPES OF PRIMARY ALDOSTERONISM: PP.18.188

Abstract

Metabolic syndrome is frequent clinical condition in the population of hypertensive subjects. Primary aldosteronism (PA) is common form of secondary hypertension. This study was aimed at investigating the prevalence of the metabolic syndrome and its components in two main forms of PA: unilateral aldosterone-producing adenoma (APA) and bilateral aldosterone overproduction due to idiopathic hyperaldosteronism (IHA). The distinction between both types of PA was based on adrenal venous sampling and/or successful surgery with histopathological examination. We analyzed clinical and laboratory data in 100 patients with PA (50 patients with IHA and 50 patients with APA) and 90 patients with essential hypertension (EH). We compared clinical and laboratory parameters between all groups of patients. The prevalence of the metabolic syndrome (62 vs 36%), the body mass index value (30 ± 4 vs. 27 ± 5) and triglycerides levels (1,9 ± 0,9 vs. 1,4 ± 0,8 mmol/l) were all significantly (p < 0,05) higher in IHA compared to APA patients. Our data thus indicate potential differences in metabolic phenotype between two main forms of PA. Metabolic profile of patients with bilateral form of PA (due to IHA) is similar to EH in contrast to unilateral form of PA (APA). According to our study it looks like that the prevalence of IHA is higher in males than in females.