Abstract

 
 
 
 Purpose: To determine new metabolites of the main components of Angelica gigas known to give anti-inflammation and pain relief
 Methods: Decursinol and blank sample were metabolized in human liver microsomes. The metabolized samples were centrifuged and deproteinated by adding 3 mL acetonitrile. The acetonitrile layer was concentrated and reconstituted in methanol. Finally, the prepared sample was injected into the LC-Q- TOF-MS.
 Results: Four new metabolites of decursinol with m/z ranging from 263.0912 ~ 263.0920 were identified as hydroxylated forms of decursinol, and the hydroxylated position of each metabolite was characterized using TOF mass spectrum. Their error values of detected m/z were 0.38 ~ 2.29 ppm, which indicates high accuracy of analysis.
 Conclusion: Previously unreported decursinol metabolites have been identified in this study. The findings provide athe basis for further pharmaceutical studies and functional food development using decursinol.
 
 
 
Highlights
IntroductionAngelica and the family Apiaceae, has been widely used in Asia as a medicinal herb for many years because of its calming, analgesic, antitumor, and brain cell protection properties
Angelica, a plant belonging to the genusAngelica and the family Apiaceae, has been widely used in Asia as a medicinal herb for many years because of its calming, analgesic, antitumor, and brain cell protection properties
Three metabolites formed through hydroxylation and dehydroxylation, two metabolites formed through the epoxidation of Decursinol M1 m/z 245.0816 (M2) M3 m/z 245.0809 (M4)
Summary
Angelica and the family Apiaceae, has been widely used in Asia as a medicinal herb for many years because of its calming, analgesic, antitumor, and brain cell protection properties. It is effective in the treatment of women's diseases such as menstrual irregularities, amenorrhea, menopausal syndrome, and postpartum abdominal pain. It is sold as a functional food for women's health care in Europe and USA [1,2,3]. The main components of Angelica gigas Nakai are decursinol, decursin, and decursinol angelate [12]. Decursinol was effective in preventing tumor cell proliferation in an in vitro study and is being marketed as “Decursinol-50” owing to its anti-inflammatory and pain-relieving effects [14,15,16,17,18]
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