Abstract
The metabolic cycle firstly considered here is composed of a unique initial substrate, six enzymes, and five empty boxes to accommodate the substrates derived from the transformation of the initial substrate. This cycle was considered as a pre-Closed Metabolic Cycle (CMC). Using this model, the influence of changing the kinetic constant values of any enzyme on the substrate concentration was explored. This model was transformed into an open metabolic cycle (OMC) by the input and output of two metabolites catalyzed by two external enzymes. In this case, the relative rates of input and output of metabolites were also examined; it can be concluded that the OMC cycles form delicate and fragile structures which can be theoretically disrupted, making them metabolically unfeasible.
Highlights
Several aspects of metabolic pathways have been lately approached in our laboratory [1]
The metabolic cycle firstly considered here is composed of a unique initial substrate, six enzymes, and five empty boxes to accommodate the substrates derived from the transformation of the initial substrate
This cycle was considered as a pre-Closed Metabolic Cycle (CMC)
Summary
Several aspects of metabolic pathways (linear or cyclic) have been lately approached in our laboratory [1]. The occurrence, properties and theoretical usefulness of closed metabolic cycles (CMC) have been considered in previous publications from this laboratory [2] [3] [4]. The OMC cycles can be studied with different and complementary approaches, among them, by measuring the level of their components and analyzing potential changes in their concentration in different metabolic or nutritional conditions. These are cumbersome procedures and sometimes difficult to be implemented [5] [6] [7]. The advances in computational techniques have allowed a more comprehensive understanding of open metabolic cycles [5] [8] [9] [10] [11] [12]
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