Abstract

The net transport of solutes across a biological membrane can, in a linear range of the system, be described as the sum of active and passive transport components. Active transport is that portion of the net transport that is observed in the absence of any electrochemical potential differences for all components across the epithelium. This active transport can be defined thermodynamically by J i act = L iA . A′ where L iA ′ is the phenomenological coefficient that couples the flow of i to the affinity of a chemical reaction A′, an equivalent to the thermodynamic force conjugated to the reaction flow (Sauer, 1973). Therefore it is this process where coupling between metablism and transport has to be expected. Accordingly, inhibition of active transport is observed when metabolic inhibitors are applied to transporting epithelia.

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