Abstract
Aims: To evaluate the relationship between daily sensor scan rates and changes in HbA1c and hypoglycemia in children. Methods: We enrolled 145 paediatric T1D patients into a prospective, interventional study of the impact of the FreeStyle Libre 1 system on measures of glycemic control. Results: HbA1c was higher at lower scan rates, and decreased as the scan rate increased to 15–20 scans, after which it rose at higher scan rates. An analysis of the change in hypoglycemia, based on the number of daily sensor scans, showed there was a significant correlation between daily scan rates and hypoglycemia. Subjects with higher daily scan rates reduced all levels of hypoglycaemia. Conclusions: HbA1c is higher at lower scan rates, and decreases as scan rate increases. Reductions in hypoglycemia were evident in subjects with higher daily scan rates.
Highlights
The FreeStyle Libre 1 flash glucose monitoring system (Abbott Diabetes Care, Witney, UK) is an established technology that measures glucose in interstitial fluid (ISF)
When we looked the changes in HbA1c across the whole study group, there was from a glucose controls wereatrelated to better control measures in hemoglobin; a significant relationship between the change in
It is interesting to observe that from 15–20 scans a day glycosylated hemoglobin was negatively influenced. This fact may be related to an infective adherence, which shows repeated ineffective acts. These data had already been published with the number of capillary glycemic controls per day, where it was seen that a greater number of capillary glucose controls were related to better control measures in hemoglobin; from a certain number it was related to caregiver anxiety, and/or the patient, without having a favorable impact on metabolic control
Summary
The FreeStyle Libre 1 flash glucose monitoring system (Abbott Diabetes Care, Witney, UK) is an established technology that measures glucose in interstitial fluid (ISF). The FreeStyle Libre sensors are calibrated in the factory and have a wear time of up to 14 days without the need for the user to perform daily calibration using finger-prick tests [1]. The FreeStyle Libre flash glucose monitoring system was proven in the IMPACT and REPLACE studies [2,3] to reduce time in hypoglycemia below 70 mg/dL by 38% (IMPACT). 43% (REPLACE) over 26 weeks, for adults with type 1 (T1D) or type 2 diabetes (T2D). On insulin, compared with the finger-prick method for the self-monitoring of blood glucose (SMBG). Neither study showed a significant change in HbA1c observed with the flash glucose monitoring compared with SMBG. In the SELFY prospective interventional singlearm study [4], which used the FreeStyle Libre system in 76 children and adolescents with
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