Abstract
The contribution of the author’s groups on the control of energy metabolism of cancer cells has been concisely reviewed. It is proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in an alteration of the recurrent filamentation cycle of mitochondria. These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells.
Highlights
Over almost the past 45 years the author has dedicated a substantial part of his efforts in experimental biochemical investigation to this problem of science
These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells
From the thousands of investigators who have devoted their lives to aerobic glycolysis and the mitochondria of tumoral cells, some third party publications, together with his own main ones, have been selected
Summary
Over almost the past 45 years the author has dedicated a substantial part of his efforts in experimental biochemical investigation to this problem of science He considers himself a disciple of Sydney Weinhouse and Britton Chance, two pioneer investigators in the studies of energy metabolism. This brief article covers his group’s contribution to this, the last riddle of cancer’s molecular physiology, without using graphs or tables, and with only a few references. Experts in this field are well versed in the contributions made by all authors in the field. The progress made in molecular genetics has been marvelous, on account of the significant funding made available over the last thirty five years due to the very worthwhile trend in cancer and genes
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