Metabolic Clues: Novel Directives for Broad Treatment Strategies

Kenneth Maiese

doi:10.4161/oxim.3.5.14254

Abstract

Metabolic Clues: Novel Directives for Broad Treatment Strategies

Highlights

In this issue of Oxidative Medicine and Cellular Longevity, our initial two papers present novel analyses of pathways of diabetes mellitus (DM) and complications of the disease
DM is a prime example of a broad-based disorder that can affect multiple cellular pathways and systems of the body to lead to complications that result in immune dysfunction, depression, hepatic dysfunction, renal disease, hematological disease, neurodegenerative disorders and cardiovascular disease
In the review paper by Haden et al, the authors open the discussion by presenting the role of pericytes in the metabolic syndrome and DM. They present strong evidence to advocate strategies that maintain this microvascular mural cell since pericytes can influence many disease processes, especially in the pancreas and skeletal muscle. In their clinical study with administration of an agent that lowers circulating cholesterol levels, Nakamura et al investigated the role of advanced glycation end products (AGEs) traditionally present during DM in a population of non-diabetic chronic kidney disease patients with dyslipidemia

Summary

Introduction

DM is a prime example of a broad-based disorder that can affect multiple cellular pathways and systems of the body to lead to complications that result in immune dysfunction, depression, hepatic dysfunction, renal disease, hematological disease, neurodegenerative disorders and cardiovascular disease. In this issue of Oxidative Medicine and Cellular Longevity, our initial two papers present novel analyses of pathways of DM and complications of the disease.

Results

Conclusion