Abstract
IN A PRELIMINARY PAPER (Schiller and Pincus 1943b) we presented data demonstrating that estradiol perfused through rat livers is converted to a ketonic estrogen (probably estrone) and to a “strong” phenolic estrogen (probably estriol).In this paper we present in detail the results of the perfusion of rat livers, kidneys, and heart tissue by various estrogens. The experimental animals employed were 225 to 250 gram female rats of the Sherman strain which were sacrificed under light ether anesthesia during proestrus. Standard aseptic conditions were maintained in preparing the organs for perfusion. Thorough and rapid bleeding of each donor was accomplished by exsanguination from the aorta. The liver in situ was, after bleeding, rapidly washed with Ringer-Locke solution, dissected and cannulated through the portal vein. The kidneys were obtained from animals which were eviscerated. All the abdominal branches of the. aorta, and the branch of the renal artery leading to the adrenals were ligatured.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
