Abstract
The relationship between serum and brain concentrations of histidine and methionine were detewrmined in rats fed graded levels of protein, histidine and methionine. In each case, changes in tissue levels of the two amino acids were inversely proportional. In protein-deficient rats, histidine increases rapidly in brain and serum while methionine decreases. Glycine and methionine supplementation of protein-deficient diets lessen increases in histidine concentrations while glycine supplementation increases growth of depleted rats placed on normal diets. These findings implicate the pathway for one-carbon metabolism in the large increases seen in histidine levels in protein deficiency.
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