Abstract
In a case of McArdle's disease (muscle phosphorylase deficiency) enzyme activities of glycogen metabolism, glycolysis and phosphoenolpyruvate metabolism were measured. Besides the deficiency of muscle phosphorylase, a marked increase in phosphoenolpyruvate carboxykinase activity was found in the muscle investigated. The increase in phosphoenolpyruvate carboxykinase activity is regarded as an adaptive mechanism providing phosphorylated intermediates for energy supply to the muscle.
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