Metabolic activity pattern in the motor and somatosensory cortex of monkeys performing a visually guided reaching task with one forelimb.

Abstract

The [14C]deoxyglucose method was used to map the metabolic activity in the primary somatosensory and motor cortex in monkeys (Macaca nemestrina) performing a unimanual task. The task required visually guided reaching and target holding at a rate of about 10 movements per min. The entire dorsoventral extent of the cortical region lying between the posterior crown of the arcuate and the anterior crown of the intraparietal sulci was reconstructed on the sagittal plane, from horizontal sections aligned on the fundus of the central sulcus. The metabolic mapping of the control monkey demonstrated homogeneous activity all around the central sulcus, bilaterally. The mapped activity in the performing monkeys displayed two different patterns. The first pattern, contralateral to the moving forelimb, was characterized by several discrete regions of increased metabolic activity, which were symmetrically distributed in a mirror image fashion around the fundus of the central sulcus. These activated regions correspond to the lower body, forelimb, and mouth areas of representation of body parts in previously reported maps in primary motor and somatosensory cortical areas. The second activity pattern ipsilateral to the moving forelimb, displayed activated somatosensory and motor regions corresponding only to the lower body, and mouth representations. Our study provides a continuous, high resolution map of activity pattern in the entire primary motor and somatosensory cortices, which demonstrates that the reaching forelimb is controlled by a discrete subregion in the contralateral somatosensorimotor cortex, whereas other subregions of body representation are actively involved, bilaterally, during the performance of a relatively simple motor behaviour.