Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients.

Abstract

The emerging role of the 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in the study ofthe metabolic activity and inflammation in adipose tissue indicates that it might be a reliable tool to complement the risk stratificationin obesity. The aims of this study were the evaluation of 18F-fluorodeoxyglucose uptake by visceral adipose tissues and subcutaneousadipose tissues and to determine eventual differences in patients with and without obesity. Retrospective study of adult patients who underwent whole body 18F-fluorodeoxyglucose-positron emissiontomography/ computed tomography scanning between July and August of 2016. SPSS™ software v.20. Statisticalsignificance: p < 0.05. We assessed fluorodeoxyglucose-positron emission tomography/computed tomography scans from 156 patients (58.3%of males) with a mean age of 61.0 ± 14.1 years. Half of the patients had a body mass index ≥ 25.0 kg/m2and 15.4% (n = 24) wereobese. In both groups, the mean 18F-fluorodeoxyglucose uptake was higher in visceral adipose tissues. There were no differences in 18F-fluorodeoxyglucose uptake in visceral adipose tissues between the groups. Obese patients had lower density of adipose tissue,both in subcutaneous adipose tissues and in visceral adipose tissues. Abdominal circumference and density of visceral adipose tissueshad a positive predictive value in the mean 18F-fluorodeoxyglucose uptake in visceral adipose tissues.Discussion: Through a non-invasive test, this study demonstrated a significant higher metabolic activity in visceral adipose tissues inboth obese and non-obese patients. According to our results, abdominal circumference was an important determinant in 18F-fluorodeoxyglucoseuptake in visceral adipose tissues. We also demonstrated that obese patients had differences in adipose tissue quality. Our findings reinforce the importance of the adipose tissue quality and distribution for metabolic risk stratification.