Abstract
1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B 1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35–50% with increasing age. 3. An age-related decrease (50–65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B 1 to mutagenic compounds was also observed.
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