Metabolic abnormalities in adolescents with polycystic ovary syndrome in south china

Jia Huang,Xiaoli Chen,Lili Huang,Renmin Ni,Dongzi Yang,Yaqin Mo

doi:10.1186/1477-7827-8-142

Abstract

BackgroundAdults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks.MethodsAnthropometric measurements and biochemical parameters were evaluated in 128 adolescents with PCOS and their age- and BMI-matched controls.ResultsThe prevalence of pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome in adolescents with PCOS was 11.7%, 46.9%, 29.7%, 22.7% and 4.7%, respectively. 16.3%, 74.4%, 67.4%, 39.5% and 14% of the PCOS subjects with BMI > 85th had pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome, whereas 9.4%, 32.9%, 10.6%, 14.1% and 0% of the PCOS subjects with BMI < 85th had such disturbances.ConclusionsAdolescents with PCOS in South China had more metabolic abnormalities than their age- and BMI-matched non-PCOS counterparts. Obesity could worsen insulin resistance, hyperinsulinemia and metabolic syndrome in PCOS adolescents.

Highlights

Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities
Demographics and anthropometrics In total, 128 adolescents were diagnosed as PCOS according to the Rotterdam criteria
No differences were found between the controls whether had given a blood sample or not, concerning age, Body mass index (BMI), duration of the period, and quantity of menstrual flow

Summary

Introduction

Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks. Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects about 6%-8% women worldwide [1]. The consequences of the PCOS extend beyond the reproductive axis; women with the disorder are at substantial risk for developing metabolic abnormalities [2]. Perpetual sequence of hormonal and metabolic aberrations in PCOS patients may commence early, even in adolescent period, and extend throughout life. Metabolic abnormalities, including pre-diabetes, dyslipidemia and metabolic syndrome (MS), have been widely studied in adult women with PCOS. There are few studies on the metabolic disturbances in adolescents with PCOS all over the world.

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