Meta-Analysis the Effect of Intrauterine Device Uptake on the Risk of Ectopic Pregnancy in Women of Reproductive Age

Abstract

Background: Indonesia has a high Maternal Mortality Rate (MMR) and has not met the Millennium Development Goals (MDGs) target. Maternal mortality in Indonesia is caused by bleeding, hypertension, infection with abortion, and prolonged labor. One of the causes of bleeding in the first trimester is ectopic preg­nancy. Several studies have shown an increased risk of ectopic pregnancy in women using intra­uterine contraceptives. Subjects and Method: A literature review was carried out in this study with a case control study design. The exposure was intrauterine contraception, and the outcome of the study was an ectopic pregnancy. The initial screening limits studies by time, language and appro­priate themes. Furthermore, the selection of research articles was carried out based on the content according to the topic, namely ectopic pregnancy and intrauterine contraceptives, the literature obtained was not duplicated, and each literature was reviewed. Statistical analy­sis was performed using Rev.Man 5.3 software with a random effects model. Value: the I² statistic was used to calculate hetero­geneity. Results: Pooled OR estimates from all studies are (RR= 1.53; 95% CI= 0.48 to 4.80; p= 0.47) with a heterogeneity of 85%. Conclusion: Based on a review of the litera­ture, it can be concluded that intrauterine contraceptives can cause ectopic pregnancy, but the results of the study still show quite varied OR. Keywords: intrauterine contraceptives, ectopic pregnancy, meta analysis Correspondence: Yulita Endah Mayaningrum. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36 A, 57126, Surakarta, Central Java 57126. Email: yulita.maya95@gmail.com. Mobile: +6285817887585. Journal of Maternal and Child Health (2021), 06(02): 165-175 https://doi.org/10.26911/thejmch.2021.06.02.04