Meta-analysis reveals a lack of association between MRP2 C-24T genetic polymorphism and the pharmacokinetics of mycophenolic acid in adult renal transplant recipients

Abstract

BackgroundRecent studies have shown that the multidrug resistance protein 2 (MRP2) C-24T genetic polymorphism is associated with the pharmacokinetics (PKs) of mycophenolic acid (MPA) in renal transplant recipients. However, published studies have reported inconsistent results. Therefore, a meta-analysis and systematic review were conducted to evaluate the effect of the MRP2 C-24T polymorphism on the PKs and safety of MPA in the literature. MethodsA comprehensive literature search was performed using the PubMed, Cochrane Library and Embase databases. Heterogeneity was assessed; forest plots were also used. In total, 10 studies with 1048 renal transplant recipients were included in our meta-analysis and systematic review. ResultsThe results showed that the MRP2 C-24T polymorphism was not associated with the PKs of MPA [AUC0–12/dose: SMD=−0.103 (−0.566, 0.361), P=0.143] using the dominant model in our analysis, and a lack of correlation was found between the C-24T polymorphism and the occurrence of biopsy-proven acute rejection (BPAR) or MPA-related adverse events in the systematic review. ConclusionsIn conclusion, our meta-analysis and systematic review suggest that the MRP2 C-24T polymorphism has no significant effect on the PKs of MPA in steady-state conditions and is not associated with the safety of MPA in adult renal transplant recipients. Moreover, further large-scale, case-control studies with rigorous designs should be carried out to confirm these conclusions.