Meta-analysis on pathogen composition of hand, foot and mouth disease reported from 2008 to 2013 in China

Abstract

Objective To find out epidemic pattern and characteristics of the pathogens causing hand,foot and mouth disease (HFMD) by Meta-analysis on pathogen-testing results published in domestic literatures.Method Articles from 2008 to 2013 in CNKI database were retrieved and analyzed by Meta-analysis with Review Manager 5.0 software.Results Twenty-four articles with total 15 360 samples were collected.The combined odds ratio (OR) of samples positive for enterovirus 71 (EV71) and coxsackievirus A16 (CA16) detected by real time PCR was 2.10 with a 95％ confidence interval (CI) of 1.37-3.23.The infection risk of EV71 was slightly higher than that of CA16 (Z=3.40,P=0.0007).The combined OR (95 ％ CI) of samples positive for enterovirus (EV),EV71 and CA16 between different genders (male and female) were 1.19 (0.97-1.46),1.01 (0.81-1.26) and 1.36 (1.04-1.78),respectively.There was a significant difference of CA16 infection risk between males and females (Z=2.23,P=0.03).The combined OR (95％ CI) of samples positive for EV,EV71 and CA16 between two age groups,0-3 years old (excluding 3 years old) and 3-6 years old (excluding 6 years old) were 1.01 (0.69-1.48),0.88 (0.58-1.35) and 0.98 (0.65-1.47),respectively.Conclusions There is slight or no difference of infection risk between EV71,CA16 and other EV in general population as well as in different gender and age.Therefore,same measures should be taken to prevent HFMD regardless of pathogens,gender and age. Key words: Enterovirus; Hand, foot and mouth disease; Meta-analysis