Meta-analysis of the relationship between drinking and cerebral hemorrhage

Abstract

Objective To study on the relationship between drinking and cerebral hemorrhage by systematic review and meta-analysis. Methods By using the method of systematic evaluation, online searches were conducted on English databases such as Ovid, MEDLINE, EMBASE and Chinese databases such as CNKI and Wanfang to retrieve the literature related to the risk of drinking and cerebral hemorrhage collected from the self-established database to May 2019. The quality of the literature was evaluated and the data were extracted. Meta-analysis was carried out using RevMan 5.3 and Stata12.0 software. Results The study included 10 articles in total. Meta-analysis showed statistically significant differences between drinking and cerebral hemorrhage (OR=0.85, 95%CI: 0.73-0.98, P=0.02). There were significant differences in the incidence of small to medium amount of alcohol drinking and cerebral hemorrhage (OR=0.69, 95%CI: 0.60-0.79, P<0.001). There was a statistically significant difference in the incidence of heavy drinking and cerebral hemorrhage (OR=1.41, 95%CI: 1.06-1.89, P=0.02). There was a statistically significant difference between female drinking and cerebral hemorrhage (OR=0.59, 95%CI: 0.48-0.72, P<0.001), there was no significant difference in male drinking and cerebral hemorrhage (OR=0.10, 95%CI: 0.89-1.14, P=0.95). In the Caucasian population, drinking is a protective factor in the occurrence of cerebral hemorrhage (OR=0.77, 95%CI: 0.61-0.97, P=0.03). Conclusion Drinking and cerebral hemorrhage have a correlation, a large number of alcohol drinking can significantly increase the incidence of cerebral hemorrhage. Key words: Alcohol; Cerebral hemorrhage; Meta-analysis