Meta-analysis of the relationship between atmospheric PM2.5 and PM10 exposure and ischemic heart disease mortality

Abstract

Objective To quantitatively evaluate the relationship between atmospheric particulate matter PM2.5, PM10 exposure and ischemic heart disease (IHD) mortality. Methods Domestic and international database were retrieved online, and the epidemiologic studies about the association between exposure to particulate matter and IHD mortality were systematically collected. Meta-analysis was performed using Stata 14.0 software. Risk estimates were combined by different effect models according to the result of heterogeneity test. Sensitivity analysis and publication bias analysis were performed. Results A total of 56 literatures were included. With PM2.5, PM10 and PM10-2.5 increasing per 10 μg/m3, the combined effect values of IHD mortality were 1.0236(95%CI: 1.0184-1.0288), 1.0106(95%CI: 1.0075-1.0137) and 0.9920(95%CI: 0.9669-1.0178), respectively. The combined effect values of acute effect of PM2.5 and PM10 on IHD mortality [1.0082(95%CI: 1.0057-1.0107); 1.0088(95%CI: 1.0064-1.0113)] were less than the chronic effect [1.2120(95%CI: 1.1470-1.2806); 1.0831(95%CI: 0.9944-1.1797)]. Compared to the European and American people[1.1010(95%CI: 1.0756-1.1269); 1.0186(95%CI: 1.0083-1.0290)], the combined effect values of exposure to PM2.5 and PM10 on IHD mortality in Asian population [1.0052(95%CI: 1.0031-1.0074); 1.0079(95%CI: 1.0049-1.0109)] were much lower. Conclusions Exposure of an increase in the concentration of atmospheric particulate matter PM2.5 and PM10 may increase the risk of IHD mortality. Key words: Atmosphere; Particulate matter; Myocardial ischemia; Mortality; Meta-analysis