Abstract

Polymorphisms of the Taq I gene have been associated with prostate cancer risk. We applied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger's test was carried out to evaluate potential publication bias. A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the T allele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01) and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT). The present meta-analysis suggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.

Highlights

  • Prostate cancer is one of the most common malignancies which harm men’s health in United States and Europe; it is the second largest tumor causing male deaths

  • Inclusion and exclusion criteria The inclusion criteria are as followings: 1) the study is based on analysis of the relationship of vitamin D receptor (VDR) gene TaqI polymorphism and genetic susceptibility to prostate cancer; 2) case-control study; 3) genotype frequency distribution; 4) age matching between treatment group and control group; the literature must be full-text

  • Basic information Through literature retrieval, we found 27 literatures were about the VDR gene TaqI polymorphism and genetic susceptibility to prostate cancer

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Summary

Introduction

Prostate cancer is one of the most common malignancies which harm men’s health in United States and Europe; it is the second largest tumor causing male deaths. Results: A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis.

Results
Conclusion
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