Abstract
LncRNA actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) is often dysregulated in cancer. We performed this meta-analysis to clarify the usefulness of AFAP1-AS1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Augest 7, 2017. Sixteen studies with a total of 1,386 patients were included in the study. The pooled hazard ratio (HR) suggested high AFAP1-AS1 expression correlated with poor overall survival (OS) (HR = 1.98, 95% confidence interval (CI): 1.71–2.28), disease-free survival (DFS) (HR = 1.54, 95% CI: 1.22–1.95), and progression-free survival (PFS) (HR = 2.17, 95% CI:1.64–2.88) in cancer patients, without obvious heterogeneity. High AFAP1-AS1 expression also correlated with larger tumor size (odds ratio (OR) = 2.04, 95% CI: 1.54–2.72), advanced tumor stage (OR=2.35, 95% CI: 1.70–3.26), poor histological grade (OR =1.39, 95% CI: 1.02–1.90), lymph node metastasis (OR = 2.71, 95% CI: 1.98–3.72) and distant metastasis (OR = 2.96, 95% CI: 2.03–4.32). Thus high AFAP1-AS1 expression is predictive of poor OS, DFS, PFS, lymph node metastasis, distant metastasis, histological grade, larger tumor size and tumor stage, which suggests high AFAP1-AS1 expression may serve as a novel biomarker of poor prognosis in cancer.
Highlights
High AFAP1-AS1 expression is predictive of poor overall survival (OS), DFS, PFS, lymph node metastasis, distant metastasis, histological grade, larger tumor size and tumor stage, which suggests high AFAP1-AS1 expression may serve as a novel biomarker of poor prognosis in cancer
The results demonstrated that high expression of AFAP1-AS1 significantly predicted more prone to developing lymph node metastasis for patients with cancer
The inclusion criteria were as follows: 1) the relationship between AFAP1-AS1 expression and survival was measured in multiple human tumors; 2) the expression levels of AFAP1-AS1 in human tumor tissue were measured, and the patients were grouped according to the expression levels of AFAP1-AS1; 3) all of the tumors were confirmed by pathological or histological examinations; 4) studies statistically analyzed patient survival or pathological parameters such as lymph node metastasis, tumor size and tumor stage, with respect to
Summary
RNA 1 (AFAP1-AS1) is a lncRNA originally detected in esophageal adenocarcinoma [11] It is derived from the antisense DNA strand in the AFAP1 gene locus, which regulates actin flament integrity, and acts as an adaptor protein that links Src family members and other signaling proteins associated with actin flaments [11, 12]. AFAP1-AS1 expression may affect prognosis and metastasis of human cancers, most studies reported so far are limited by discrete outcomes and sample size. We performed this update metaanalysis to determine the prognostic value of AFAP1-AS1 in cancer patients. Our analyses did not find any significant heterogeneity among the studies This result demonstrated that a high expression of AFAP1-AS1 might be correlated with a shorter OS, DFS and PFS in cancer patients. We found that AFAP1AS1 was an independent factor of survival among patients with cancer
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