Meta-analysis of the efficacy of platelet-rich plasma in the treatment of severe burns

Abstract

Objective To evaluate the efficacy of platelet-rich plasma(PRP) in the treatment of severe burns by Meta-analysis method, and to provide scientific basis for clinical medication. Methods The data of clinical controlled trials such as EMBase, PubMed, CBM, CNKI, VIP, Wanfang and Cochrane were retrieved by computer. Meanwhile, the references of the literatures were screened and included in the randomized controlled trials of PRP in the treatment of severe burns(the retrieval time of all databases ranged from creation to April 2019). Data were independently extracted by two evaluators to check and evaluate the quality of literature. Cochrane chi-square test was used to analyze the data. Results Six articles were included in this study. Meta-analysis showed that the total effective rate of platelet-rich plasma treatment group [RR=1.17, 95%CI (1.08, 1.26), P<0.0 001], wound healing time [RR=-4.98, 95%CI (-7.60, -2.36), P=0.0 002], scar index [RR=-1.70, 95%CI (-2.09, -1.30), P<0.00 001] and visual analogue scale (VAS) score [RR=-2.54, 95% CI (-3.73, -1.34), P<0.00 001], there were significant differences between the treatment group and the control group (P<0.05). Conclusion Based on the existing clinical evidence, PRP is superior in the treatment of severe burns, but this conclusion still needs to be confirmed by a higher quality clinical randomized controlled trial. Key words: Platelet-rich plasma; Burns; Validation Studies; Meta-analysis