Abstract
Sepsis is one of the main causes of death in burn patients, and many studies have suggested that procalcitonin (PCT) is a biomarker for the early diagnosis of sepsis, but the results are controversial. The aim of this study was to evaluate the diagnostic value of serum PCT in adult burn sepsis by conducting a meta-analysis of published studies. The PubMed, Embase, Web of Science, CNKI and China Wanfang databases were searched, and studies on PCT as a marker for the diagnosis of adult burn sepsis from the establishment of the database, to February 1, 2020 were screened. The data were analyzed using Stata v. 15.0 software. A total of 10 studies and 704 patients were included. The combined sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) were 0.67 (95% CI: 0.48-0.81), 0.87 (95% CI: 0.72-0.95), 5.20 (95% CI: 2.49-10.84), 0.38 (95% CI: 0.24-0.61) and 13.70 (95% CI: 5.72-32.82), respectively. The area under the summary receiver operating characteristic curve (SROC) was 0.85 (95% CI: 0.82-0.88), and the diagnostic threshold was the main source of heterogeneity. Results demonstrate that serum PCT may be used as a useful biomarker for the early diagnosis of burn sepsis in adults, and may be combined with other diagnostic indexes to further improve the sensitivity and specificity.
Highlights
Burns are common injuries in life and war
The use of prophylactic antibiotics in severe burn patients leads to a low positive rate of blood culture, which leads to a delay in the diagnosis of burn sepsis and an increase in antibiotic resistance.[5]
When retrieving statistics related to vital signs and blood samples collected at a specific time point, according to the diagnostic criteria of sepsis, each time point was defined as either sepsis or non-sepsis, and divided into a sepsis group and non-sepsis group
Summary
There are many strategies for the prevention and treatment of infection in burns, burn sepsis is still one of the common causes of death in patients with severe burns.[1] Burns, especially severe burns, can lead to extensive damage to the skin tissue, the body’s first defense barrier, resulting in serious damage to the body’s internal homeostasis, a decrease in immunity, and a large volume of necrotic wound tissue. These changes provide good conditions for the growth and reproduction of bacteria. Such an indicator would facilitate timely treatment measures, guide the use of antibiotics, and increase the survival rate of patients with burn sepsis
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