Meta-analysis of the association of ADIPOQ G276T polymorphism with insulin resistance and blood glucose.

Abstract

Insulin resistance (IR) is a major risk for the development of type 2 diabetes (T2D). Numerous studies have been conducted to determine the relationship of ADIPOQ G276T with IR and blood glucose, but the results are conflicting. We conducted a meta-analysis in this work to further investigate such an association. Published works were retrieved from PubMed and Embase databases. A pooled standardized mean difference (SMD) with 95 % confidence interval (CI) was calculated under a dominant model using a random effect model. Twenty-five studies involving 7,480 subjects were included in the meta-analysis. A significant association of G276T polymorphism with homeostasis model assessment insulin resistance index (HOMA-IR) was observed after excluding studies with obvious heterogeneity by performing influence analysis (SMD = -0. 08, 95 % CI -0.15 to -0.01, p = 0.019) and Galbraith plot analysis (SMD = -0.08, 95 % CI -0.14 to -0.02, p = 0.005). In the subgroup analysis, Asians with TG/TT genotypes were found to have a significantly decreased degree of HOMA-IR (SMD = -0.13, 95 % CI -0.20 to -0.07, p < 0.001). The association of G276T with IR or blood glucose for the subgroups (obese, male, and T2D) was also significant. However, the results may not be reliable for small sample sizes. The current meta-analysis suggested that the G276T polymorphism may genetically affect IR using HOMA-IR as an index, and the effect of this polymorphism on IR particularly exists in Asians.