Abstract
BackgroundAlzheimer’s disease is a common neurodegenerative disorder in elderly. This study was aimed to systematically evaluate the association between tea intake and the risk of cognitive disorders by meta-analysis.Methods and FindingsPubMed, Embase and Wanfang databases were systematically searched and a total of 26 observational studies were included in this study. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated and pooled by using fixed or random effects models according to the degree of heterogeneity.ResultsThe overall pooled analysis indicated that tea intake could significantly reduce the risk of cognitive disorders (OR = 0.65, 95%CI = 0.58–0.73). Subgroup analyses were conducted based on study design, population, frequency of tea drinking and type of cognitive disorders. The results showed that tea drinking was significantly associated with the reduced incidence of cognitive disorders in all of subgroups based on study design and frequency of tea drinking. In particular, tea drinking was inversely associated with the risk of cognitive impairment (CoI), mild cognitive impairment (MCI), cognitive decline and ungrouped cognitive disorders. Moreover, for population subgroups, the significant association was only found in Chinese people.ConclusionOur study suggests that daily tea drinking is associated with decreased risk of CoI, MCI and cognitive decline in the elderly. However, the association between tea intake and Alzheimer’s disease remains elusive.
Highlights
Cognitive disorders are a category of mental disease that affects memory, language, learning and problem solving
The overall pooled analysis indicated that tea intake could significantly reduce the risk of cognitive disorders (OR = 0.65, 95%confidence intervals (CIs) = 0.58–0.73)
The results showed that tea drinking was significantly associated with the reduced incidence of cognitive disorders in all of subgroups based on study design and frequency of tea drinking
Summary
Cognitive disorders are a category of mental disease that affects memory, language, learning and problem solving. Alzheimer’s disease (AD) and cognitive impairment (CoI) are two common cognitive disorders in elderly and negatively affect the elders’ life. Because of limited treatment of cognitive disorders, the prevention or onset delay of the disease through modification of risk factors such as lifestyles are proposed [3,4]. Some lifestyles, such as folic acid supplementation [5], flavonoid-rich food [6] and caffeine contained drinks [7] have been reported to be inversely associated with the risk of cognitive disorders. This study was aimed to systematically evaluate the association between tea intake and the risk of cognitive disorders by meta-analysis
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