Abstract
To clarify the effects of selenium level on the risk of gastric cancer (GC) and GC mortality, a meta-analysis was performed. Related studies were identified from PubMed, EMBASE, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM). Pooled ORs and 95% CIs were used to assess the strengthof the associations. A total of 8 studies including 17834 subjects were involved in this meta-analysis. High selenium level was associated with GC risk in case-control study (OR = 0.62, 95% CI 0.44–0.89, P = 0.009; I2 = 52%) and cohort study (OR = 0.87, 95% CI 0.78–0.97, P = 0.01; I2 = 25%). In addition, high selenium level was associated with GC mortality risk (OR = 0.90, 95% CI 0.84–0.97, P = 0.006, I2 = 49%). In summary, this meta-analysis suggested that selenium might inversely associated with GC risk and GC mortality.
Highlights
Gastric cancer (GC) represents a serious health problem on a global scale [1]
We did this meta-analysis to estimate the relationship between selenium level and susceptibility to GC and mortality
In the subgroup analyses by study design, race, and duration follow-up, we found these factors did not influence the role of low selenium level in the development of GC
Summary
Gastric cancer (GC) represents a serious health problem on a global scale [1]. It is highly prevalent in Asia and is one of the leading causes of cancer-related death worldwide [1]. Charalabopoulos and colleagues suggested thatserum selenium levels were lower in the GC patient group than that in healthy individuals [5]. They found an inverse correlation between selenium and carcinoembryonic antigen (CEA) serum levels [5].
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